Thornton SL, Whitacre J, Pallo N, Roberts N, Oller L. In the announcement, the FDA concluded that prescribing information did not provide adequate warnings about the serious risks and harms associated with these drugs, thus increasing the risk of adverse effects, especially when BZDs are used with some other medicines and substances.
In 2020, the US Food and Drug Administration (FDA) updated the required boxed warnings and package inserts for all BZDs to include information on the potential for abuse, addiction, and other serious risks. Treatment of BZD withdrawal is typically with a long-acting BZD (eg, clonazepam), but sucessful use of antiseizure drugs (eg, valproate, carbamazepine) has also been reported. Alprazolam (Xanax) withdrawal syndrome may be especially severe, with associated delirium, psychosis, and hyperadrenergic states. For additional information visit Linking to and Using Content from MedlinePlus.In long-term users who have developed dependence, cessation of BZDs can result in a withdrawal syndrome, with manifestations including anxiety, irritability, confusion, seizures, and sleep disorders. Any duplication or distribution of the information contained herein is strictly prohibited without authorization.
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